Drug induced liver injury secondary to interferon-beta (IFN-beta) in multiple sclerosis.
نویسندگان
چکیده
Post marketing studies of Interferon-beta (IFN beta) therapy in multiple sclerosis (MS) have demonstrated surprisingly high rates of hepatotoxicity. Grade 3 hepatotoxicity (AST and ALT > 5 to 20 upper limit normal) or higher has been observed in as many as 1.4% of MS patients on IFN beta. We report three cases of IFN beta induced hepatitis in MS and discuss the pathology findings and possible mechanisms of drug-induced liver injury.
منابع مشابه
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عنوان ژورنال:
- Annals of hepatology
دوره 5 1 شماره
صفحات -
تاریخ انتشار 2006